Overall, features extracted from the original image showed the highest ICC, with a median of 0.91 (IQR 0.86–0.95), whereas features extracted from the exponential filtered image yielded the lowest ICC with a median of 0.82 (IQR 0.74–0.89). The most reproducible features were the minimums of the original image and the logarithm and square root filtered image (all ICC = 0.99), whereas the least reproducible features were the grey level non uniformity of the exponential and gradient filtered image (both ICC = 0.00). Out of 1320 features, 820 appeared reproducible, with an ICC ≥ 0.8. Patients’ median left ventricular ejection fraction was 67% (IQR 37–67%). Results Our final study population counted 66 patients with acute myocarditis, with a median age of 28 years (IQR 20–44 years), 56 (85%) of whom were males. Data were reported as median and interquartile range (IQR). Features were deemed reproducible when their inter-reader intra-class correlation coefficient (ICC) was ≥ 0.8. Afterwards we performed a radiomics extraction from 5 individual classes using 7 image filters, totalling 1320 individual features. From each CMR examination two readers segmented the epicardium and endocardium of the left ventricle on all short-axis slices from LGE sequences. Methods & Materials We retrospectively included all patients with acute myocarditis who underwent CMR at our institution between March 2014 and December 2020. Purpose/Objectives To review the inter-reader reproducibility of various radiomics features extracted from late gadolinium enhancement (LGE) sequences at cardiac magnetic resonance (CMR) in patients with acute myocarditis. Secchi 1,3ġUniversità degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Milano, Italy, 2ASST Nord Milano, Milano, Italy, 3IRCCS Policlinico San Donato, San Donato Milanese, Italy.
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